Alternative splicing is a driving force that tunes metabolic adaptations to virulence traits in the dermatophyte Trichophyton rubrum
Our data indicate that mRNA isoforms originating from AS contribute to the adaptation of <i>T. rubrum</i>, demonstrating that AS of transcription factor genes plays a central role in fungal pathogenesis. The transcription and splicing machinery tune fungal physiology to achieve an optimal metabolic balance in virulence traits during infection.
Authors
- Pablo Rodrigo Sanches (ORCID: https://orcid.org/0000-0002-8942-8905)
- Nilce Maria Martinez-Rossi (ORCID: https://orcid.org/0000-0002-5723-4276)
- Marcos Eduardo Ramos Lopes
- João Neves‐da‐Rocha (ORCID: https://orcid.org/0000-0002-1779-9010)
- Antônio Rossi (ORCID: https://orcid.org/0000-0003-1951-4741)
- Vanderci Massaro de Oliveira
Institutions
- Universidade de Ribeirão Preto (BR)
- Universidade de São Paulo (BR)
- Clinics Hospital of Ribeirão Preto (BR)
Publication Details
- Journal
- Frontiers in Cellular and Infection Microbiology
- Published
- 2025-09-10
- DOI
- https://doi.org/10.3389/fcimb.2025.1645525
- Citations
- 2
- Primary Topic
- Nail Diseases and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 2.71
Funders
- Fundação de Amparo à Pesquisa do Estado de São Paulo
- Conselho Nacional de Desenvolvimento Científico e Tecnológico