Real-world treatment patterns and clinical outcomes among elderly patients with locoregionally advanced head and neck squamous cell carcinoma in the United States
In elderly patients with LA HNSCC, surgery followed by RT and definitive RT+ST were the most common treatment modalities in the resected and unresected cohorts, respectively. The suboptimal real-world survival of both groups highlights the significant unmet need for more effective therapies. The positive associations between rwEFS and rwOS in both the resected and unresected cohorts support EFS as a predictor of OS when OS data are immature in LA HNSCC.
Authors
- Yuexin Tang (ORCID: https://orcid.org/0000-0001-6528-4145)
- Nati Lerman (ORCID: https://orcid.org/0000-0002-8744-7950)
- Glenn J. Hanna (ORCID: https://orcid.org/0000-0002-9969-2523)
- Yan Song (ORCID: https://orcid.org/0000-0002-7566-2813)
- James Signorovitch (ORCID: https://orcid.org/0000-0002-4067-8962)
- Behzad Bidadi
- Sanjay Merchant
- Dandan Zheng (ORCID: https://orcid.org/0009-0004-3148-5247)
- Jiayang Li (ORCID: https://orcid.org/0000-0001-9271-3988)
- Rui Song (ORCID: https://orcid.org/0000-0002-4119-4433)
- Su Zhang (ORCID: https://orcid.org/0000-0001-5962-1758)
- Anyu Zhu
Institutions
- Merck & Co., Inc., Rahway, NJ, USA (United States) (US)
- Dana-Farber Cancer Institute (US)
- Analysis Group (United States) (US)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2025-09-10
- DOI
- https://doi.org/10.3389/fonc.2025.1606990
- Citations
- 1
- Primary Topic
- Head and Neck Cancer Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.85
Funders
- California Department of Public Health
- University of Southern California
- Centers for Disease Control and Prevention
- University of California, San Francisco
- National Cancer Institute