Oolong tea attenuates neuroinflammation by modulating the microbiota-gut-brain axis in a rat model of autism
OT attenuates ASD-like phenotypes and neuroinflammation in VPA-treated rats by rebalancing gut microbiota, restoring intestinal/BBB barriers, and inhibiting neuronal TLR-4/IκB-α/NF-κB signaling. This study highlights OT's potential as a microbiota-targeted therapeutic strategy for ASD.
Authors
- Zhen Zheng (ORCID: https://orcid.org/0000-0001-6866-1903)
- Shaoqun Liu (ORCID: https://orcid.org/0000-0003-3255-3710)
- Hongbo Zhao (ORCID: https://orcid.org/0000-0001-6829-6571)
- Peng Zheng (ORCID: https://orcid.org/0000-0002-9864-6832)
- Qing Wu (ORCID: https://orcid.org/0000-0001-5447-7662)
- Xingliang Zhang
Institutions
- South China Agricultural University (CN)
- Sun Yat-sen University (CN)
- Third Affiliated Hospital of Sun Yat-sen University (CN)
- Shenzhen Children's Hospital (CN)
Publication Details
- Journal
- Frontiers in Nutrition
- Published
- 2025-09-10
- DOI
- https://doi.org/10.3389/fnut.2025.1643147
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 0.00