Integrated analysis of single-cell and bulk transcriptomics reveals the prognostic value and underlying mechanisms of crotonylation in ovarian cancer

We elucidated the significant impact of crotonylation on the ovarian cancer microenvironment and prognosis. We developed and validated a novel prognostic model for ovarian cancer that can serve as a tool for predicting patient outcomes and characterizing the immune microenvironment. These findings enhance our understanding of the role of crotonylation in ovarian cancer and establish a robust framework for developing therapeutic strategies targeting crotonylation.

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Publication Details

Journal
Frontiers in Immunology
Published
2025-09-10
DOI
https://doi.org/10.3389/fimmu.2025.1596080
Primary Topic
Ferroptosis and cancer prognosis
Type
article
Field-Weighted Citation Impact
0.00
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article

Integrated analysis of single-cell and bulk transcriptomics reveals the prognostic value and underlying mechanisms of crotonylation in ovarian cancer

Jie Tao, Xiaofeng Li, Xiaoqing Guo, Weimin Wu
Frontiers in Immunology
Ferroptosis and cancer prognosis
article

Integrated analysis of single-cell and bulk transcriptomics reveals the prognostic value and underlying mechanisms of crotonylation in ovarian cancer

Jie Tao, Xiaofeng Li, Xiaoqing Guo, Weimin Wu
article en

Abstract

We elucidated the significant impact of crotonylation on the ovarian cancer microenvironment and prognosis. We developed and validated a novel prognostic model for ovarian cancer that can serve as a tool for predicting patient outcomes and characterizing the immune microenvironment. These findings enhance our understanding of the role of crotonylation in ovarian cancer and establish a robust framework for developing therapeutic strategies targeting crotonylation.

Frontiers in ImmunologyVol. 16
Shanghai First Maternity and Infant Hospital (CN)
Openalex Percentile: Top 65%
Ferroptosis and cancer prognosis
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