Integrated analysis of single-cell and bulk transcriptomics reveals the prognostic value and underlying mechanisms of crotonylation in ovarian cancer
We elucidated the significant impact of crotonylation on the ovarian cancer microenvironment and prognosis. We developed and validated a novel prognostic model for ovarian cancer that can serve as a tool for predicting patient outcomes and characterizing the immune microenvironment. These findings enhance our understanding of the role of crotonylation in ovarian cancer and establish a robust framework for developing therapeutic strategies targeting crotonylation.
Authors
- Jie Tao (ORCID: https://orcid.org/0000-0002-2027-2287)
- Xiaofeng Li (ORCID: https://orcid.org/0000-0001-5888-7845)
- Xiaoqing Guo (ORCID: https://orcid.org/0009-0008-8883-1349)
- Weimin Wu
Institutions
- Shanghai First Maternity and Infant Hospital (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-09-10
- DOI
- https://doi.org/10.3389/fimmu.2025.1596080
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00