To explore the dose optimization of imatinib in children with liver dysfunction based on the PBPK model
Aims: This study focused on how the drug imatinib works in children with liver issues. Currently, there are no guidelines on the right dose for these children. The goal is to help doctors use this drug correctly in various medical situations. Methods:
Authors
- Keqin Liu (ORCID: https://orcid.org/0000-0002-7995-7125)
- Aiwen Jiang (ORCID: https://orcid.org/0000-0002-8332-1824)
- Pan Pang
- Gang Cheng (ORCID: https://orcid.org/0000-0002-8312-4599)
- Zehui Zhang (ORCID: https://orcid.org/0009-0004-6585-8187)
Institutions
- Shenyang Pharmaceutical University (CN)
- Hebei North University (CN)
Publication Details
- Published
- 2025-09-10
- DOI
- https://doi.org/10.22541/au.175748243.33758299/v1
- Primary Topic
- Chronic Myeloid Leukemia Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00