Mature dengue virus particles inactivated by a non-ionic detergent retain quaternary neutralizing epitopes and induce potent neutralizing antibodies
Our results suggest that Tween 20-inactivated mature particles are a promising strategy for DENV vaccine development.
Authors
- Wen-Yang Tsai
- Jens Wrammert (ORCID: https://orcid.org/0000-0002-1733-4424)
- James E. Crowe (ORCID: https://orcid.org/0000-0002-0049-1079)
- Theodore C. Pierson (ORCID: https://orcid.org/0000-0002-3795-4348)
- Juthathip Mongkolsapaya (ORCID: https://orcid.org/0000-0003-3416-9480)
- Wanwisa Dejnirattisai
- Amonrat Jumnainsong (ORCID: https://orcid.org/0000-0002-1018-4232)
- Wei‐Kung Wang (ORCID: https://orcid.org/0000-0002-6670-4663)
- Gavin Robert Screaton (ORCID: https://orcid.org/0000-0002-3549-4309)
Institutions
- University of Hawaiʻi at Mānoa (US)
- Emory Healthcare (US)
- Siriraj Hospital (TH)
- Centre for Human Genetics (GB)
- Emory University (US)
- Khon Kaen University (TH)
- John Radcliffe Hospital (GB)
- National Institute of Allergy and Infectious Diseases (US)
- Atlanta VA Medical Center (US)
- Vanderbilt University Medical Center (US)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-09-10
- DOI
- https://doi.org/10.3389/fimmu.2025.1626823
- Primary Topic
- Mosquito-borne diseases and control
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Hawaii Community Foundation
- Institute for Research in Biomedicine
- Academia Sinica
- National Institutes of Health
- National Institute of General Medical Sciences
- National Institute of Allergy and Infectious Diseases