Organotypic Culture of Adult Vascularized Porcine Retina Explants In Vitro on Nanotube Scaffolds
We demonstrate that titania nanotube arrays are highly promising as culturing scaffold of vascularized retina explants in vitro due to highly tunable surface properties regarding biomedical signaling. The unprecedented maintenance of tissue integrity allows for screening of pharmacological drugs and disease mechanisms in an ex-vivo test-based culture system with reduced need for animal experiments.
Authors
- Solveig Weigel
- Sabrina Friebe (ORCID: https://orcid.org/0000-0002-5355-6817)
- Mike Francke (ORCID: https://orcid.org/0000-0002-0932-8825)
- Stefan G. Mayr (ORCID: https://orcid.org/0000-0002-0969-8738)
Institutions
- University Hospital Leipzig (DE)
- University Hospital in Halle (DE)
- Leibniz Institute of Surface Engineering (DE)
- Leipzig University (DE)
Publication Details
- Journal
- Biological Procedures Online
- Published
- 2025-09-08
- DOI
- https://doi.org/10.1186/s12575-025-00301-5
- Primary Topic
- Retinal Development and Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Bundesministerium für Bildung und Forschung