Influence of biologic sex and obesity on liver recurrence and survival in patients undergoing upfront surgery for pancreatic adenocarcinoma
After curative surgery for pancreatic cancer, females with obesity have a significantly lower rate of liver recurrence and the longest median overall survival. This does not appear to be related to surgical quality, receipt of adjuvant therapy, or tumor mutational profile. Investigation into host immune, metabolic, and hormonal parameters is paramount to understanding these differences.
Authors
- Alice C. Wei (ORCID: https://orcid.org/0000-0002-2505-959X)
- Robert J. Torphy (ORCID: https://orcid.org/0000-0003-3941-0886)
- Michael I. D’Angelica (ORCID: https://orcid.org/0000-0002-3731-0534)
- T.P. Kingham (ORCID: https://orcid.org/0009-0003-4595-8749)
- Wungki Park (ORCID: https://orcid.org/0000-0002-8006-3102)
- Caitlin A. McIntyre (ORCID: https://orcid.org/0000-0002-7206-2433)
- William R. Jarnagin (ORCID: https://orcid.org/0000-0002-1635-5768)
- Mithat Gönen (ORCID: https://orcid.org/0000-0001-8683-8477)
- Alice Zervoudakis (ORCID: https://orcid.org/0009-0000-4818-7933)
- Kevin C. Soares (ORCID: https://orcid.org/0000-0002-0406-017X)
- Vinod P. Balachandran (ORCID: https://orcid.org/0000-0002-2956-223X)
- Sean J. Judge (ORCID: https://orcid.org/0000-0002-1842-9468)
- Emily Manin (ORCID: https://orcid.org/0000-0002-9077-2041)
- Eileen Mary O'Reilly (ORCID: https://orcid.org/0000-0002-8076-9199)
- Jeffrey A. Drebin (ORCID: https://orcid.org/0000-0003-2312-2062)
- Joanne Chou
Institutions
- Memorial Sloan Kettering Cancer Center (US)
- Cornell University (US)
- University of California Davis Medical Center (US)
- Weill Cornell Medicine (US)
- University of California, Davis (US)
Publication Details
- Journal
- Cancer
- Published
- 2025-09-10
- DOI
- https://doi.org/10.1002/cncr.70088
- Citations
- 1
- Primary Topic
- Pancreatic and Hepatic Oncology Research
- Type
- article
- Field-Weighted Citation Impact
- 1.05
Funders
- National Institutes of Health
- National Cancer Institute