Epidemiology, resistance profiles, and risk factors of multidrug- and carbapenem-resistant Serratia marcescens infections: a retrospective study of 242 cases
This study reveals substantial differences in antimicrobial susceptibility between MDR and non-MDR S. marcescens isolates and highlights amikacin and sulfamethoxazole as potential treatment options against MDR strains. Didentified clinical risk factors-including prior hospitalization, kidney disease, and extensive antibiotic exposure-underscore the importance of early risk stratification and optimized antibiotic stewardship.
Authors
- Han Shen (ORCID: https://orcid.org/0000-0001-7538-6823)
- Xiaoli Cao (ORCID: https://orcid.org/0000-0001-5928-6304)
- Chang Liu (ORCID: https://orcid.org/0000-0002-6475-5619)
- Yan Zhang (ORCID: https://orcid.org/0009-0007-3025-4289)
- Yuxin Chen (ORCID: https://orcid.org/0000-0002-4653-5276)
- Fengyan Li (ORCID: https://orcid.org/0000-0002-2386-7702)
- Hong Zhu (ORCID: https://orcid.org/0000-0003-1601-3407)
Institutions
- Nanjing Drum Tower Hospital (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- BMC Infectious Diseases
- Published
- 2025-09-09
- DOI
- https://doi.org/10.1186/s12879-025-11569-z
- Citations
- 2
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 1.18
Funders
- National Natural Science Foundation of China
- Nanjing University