Familial Alzheimer's disease mutation identifies novel role of SORLA in release of neurotrophic exosomes
Familial Alzheimer's disease mutation in SORL1 changes interactome of mutant Sortilin-related receptor with A-type repeats (SORLA). Mutant SORLA impairs release of exosomes from neurons and microglia. Mutant exosomes lack neurotrophic qualities. Defect linked to alterations in microRNA content.
Authors
- Kristian Juul‐Madsen (ORCID: https://orcid.org/0000-0002-5309-5221)
- Duncan Stewart Sutherland (ORCID: https://orcid.org/0000-0002-5045-9915)
- Matthias Selbach (ORCID: https://orcid.org/0000-0003-2454-8751)
- Thomas E. Willnow (ORCID: https://orcid.org/0000-0001-9515-7921)
- Malgorzata Gorniak (ORCID: https://orcid.org/0000-0003-1236-8622)
- Katrina Meyer (ORCID: https://orcid.org/0000-0002-8244-6887)
- Johan Palmfeldt (ORCID: https://orcid.org/0000-0001-5585-639X)
- Fabia Febbraro (ORCID: https://orcid.org/0000-0001-8336-2776)
- Narasimha Swamy Telugu (ORCID: https://orcid.org/0000-0003-4509-7056)
- Sebastian Diecke (ORCID: https://orcid.org/0000-0002-5219-5992)
- Olav M. Andersen (ORCID: https://orcid.org/0000-0003-4226-3354)
- Ina‐Maria Rudolph (ORCID: https://orcid.org/0000-0002-3903-0755)
- Malthe von Tangen Sivertsen
- Jemila P. Gomes (ORCID: https://orcid.org/0009-0004-1027-8599)
- Peter Lund Ovesen (ORCID: https://orcid.org/0000-0001-8801-4711)
- Marianna Kokoli (ORCID: https://orcid.org/0000-0002-1411-3730)
Institutions
- Aarhus University (DK)
- Max Delbrück Center (DE)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-09-01
- DOI
- https://doi.org/10.1002/alz.70591
- Citations
- 1
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- Alzheimer Forschung Initiative
- Lundbeckfonden
- Novo Nordisk
- Novo Nordisk Fonden
- H. Lundbeck A/S