Effect of Acute Administration of Different Ketamine Doses on Anxiety and Metabolic Activity of the Amygdala in Rats
We conclude that the administration of subanaesthetic doses of ketamine exerts an acute anxiogenic effect in the plus maze test at the lower doses, accompanied by a decrease in amygdala metabolic activity, suggesting metabolic exhaustion. The higher doses reversed the anxiety parameters, suggesting an explanation of the opposite symptoms in schizophrenia progression.
Authors
- Pascual Ángel Gargiulo (ORCID: https://orcid.org/0000-0003-2962-4346)
- Manuel Alejandro Guevara (ORCID: https://orcid.org/0000-0001-5545-2037)
- Esteban Alejandro Romanowicz
- Silvia Menéndez (ORCID: https://orcid.org/0000-0001-6074-9601)
- Iker Barrutieta-Arberas (ORCID: https://orcid.org/0000-0002-7643-349X)
- José Vicente Lafuente (ORCID: https://orcid.org/0000-0001-7246-0987)
- Adriana Inés Landa de Gargiulo (ORCID: https://orcid.org/0000-0002-7008-2932)
Institutions
- Aconcagua University (AR)
- Universidad Nacional de Cuyo (AR)
- University of the Basque Country (ES)
- Instituto de Medicina y Biología Experimental de Cuyo (AR)
Publication Details
- Journal
- Neuropsychobiology
- Published
- 2025-09-09
- DOI
- https://doi.org/10.1159/000547982
- Primary Topic
- Tryptophan and brain disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00