Rifampin Exposure in Pregnant and Nonpregnant Women With Tuberculosis in India
This prospective cohort study evaluated rifampin pharmacokinetics in pregnant and nonpregnant women with tuberculosis in India. Pregnant women had significantly lower drug exposure, with <20% of the participants achieving target concentrations at any trimester. Findings highlight potential underdosing in pregnancy and underscore the need for dedicated pharmacokinetics studies in pregnancy, and revised rifampin dosing guidelines.
Authors
- Jayalakshmy Ramakrishnan (ORCID: https://orcid.org/0000-0002-7798-5616)
- Selby Knudsen (ORCID: https://orcid.org/0000-0002-2470-3101)
- Noyal Mariya Joseph (ORCID: https://orcid.org/0000-0001-6586-2742)
- Sonali Sarkar (ORCID: https://orcid.org/0000-0003-0528-6805)
- Scott K. Heysell (ORCID: https://orcid.org/0000-0002-2040-0293)
- Padmini Salgame (ORCID: https://orcid.org/0000-0003-2245-3767)
- Prakash Babu Narasimhan (ORCID: https://orcid.org/0000-0001-7111-7124)
- Pranay Sinha (ORCID: https://orcid.org/0000-0002-4233-0871)
- Madolyn Rose Dauphinais (ORCID: https://orcid.org/0000-0003-4319-9788)
- Prakruti Rao
- Senbagavalli Prakash Babu
- David L. Hom (ORCID: https://orcid.org/0009-0003-0778-2076)
- Jerrold J. Ellner (ORCID: https://orcid.org/0000-0001-6150-0082)
- C. Robert Horsburgh (ORCID: https://orcid.org/0000-0001-6838-7895)
- Komala Ezhumalai
- Natasha S. Hochberg (ORCID: https://orcid.org/0000-0002-5449-9973)
- Chelsie Cintron (ORCID: https://orcid.org/0000-0001-6981-1061)
Institutions
- Rutgers, The State University of New Jersey (US)
- Boston University (US)
- Boston Medical Center (US)
- Sri Balaji Vidyapeeth University (IN)
- Rutgers New Jersey Medical School (US)
- University of Virginia (US)
- Jawaharlal Institute of Post Graduate Medical Education and Research (IN)
Publication Details
- Journal
- The Journal of Infectious Diseases
- Published
- 2025-09-09
- DOI
- https://doi.org/10.1093/infdis/jiaf467
- Primary Topic
- Pregnancy and Medication Impact
- Type
- article
- Field-Weighted Citation Impact
- 0.00