Expert consensus regarding the clinical application of liver contrast-enhanced US with Sonazoid (Sonazoid CEUS)
Sonazoid, a combined blood pool and Kupffer-cell agent, can be specifically phagocytosed by Kupffer cells in the liver, allowing lesion detection and characterization of focal liver lesions (FLLs) at the post-vascular phase, apart from the vascular phase, which is similar to that of other second-generation ultasound (US) contrast agents. Sonazoid contrast-enhanced US (CEUS) is currently approved for use in some Asian countries. With the increasing use of Sonazoid CEUS for FLLs in clinical practice, developing consensus or guidelines to help standardize its use is required. The expert consensus aimed to review recent evidence and make evidence-based recommendations for radiologists and clinicians involved in the management of liver diseases regarding the use of Sonazoid CEUS in the surveillance or detection, characterization of FLLs, CEUS for interventional and intraoperative use, and tumor treatment response evaluation in patients with FLLs. This consensus was conducted without using artificial intelligence tools in accordance with the TITAN Guidelines 2025.
Authors
- Yan Luo (ORCID: https://orcid.org/0000-0001-7073-6150)
- Ping Liang (ORCID: https://orcid.org/0000-0001-8933-6392)
- Yuanyi Zheng (ORCID: https://orcid.org/0000-0002-5532-7604)
- Kaiyan Li (ORCID: https://orcid.org/0000-0003-3332-6325)
- Tianan Jiang (ORCID: https://orcid.org/0000-0002-7672-8394)
- Hongguang Wang (ORCID: https://orcid.org/0000-0002-7447-5178)
- Xi Wei (ORCID: https://orcid.org/0000-0003-4734-3900)
- Ming-An Yu (ORCID: https://orcid.org/0000-0003-0797-4564)
- Meng Yang (ORCID: https://orcid.org/0000-0002-4339-0411)
- Hui‐Xiong Xu (ORCID: https://orcid.org/0000-0002-8699-854X)
- Xuan Meng (ORCID: https://orcid.org/0000-0002-0257-9509)
- Guangjian Liu (ORCID: https://orcid.org/0000-0001-9275-9214)
- Jie Yu (ORCID: https://orcid.org/0000-0002-1168-8766)
- Binkui Li (ORCID: https://orcid.org/0000-0003-3201-2914)
- Jianhui Yang (ORCID: https://orcid.org/0000-0002-8710-1722)
- Wei Wu (ORCID: https://orcid.org/0000-0003-1834-5931)
- Dong Xu (ORCID: https://orcid.org/0000-0002-0583-240X)
- Jing Xiang (ORCID: https://orcid.org/0000-0002-2977-1410)
- Xin‐Wu Cui (ORCID: https://orcid.org/0000-0003-3890-6660)
- Xiaoling Yu (ORCID: https://orcid.org/0000-0003-1349-2334)
- Qiu Li (ORCID: https://orcid.org/0000-0002-9128-7005)
- Ke Lv (ORCID: https://orcid.org/0000-0001-8779-9860)
- Guangzhi He (ORCID: https://orcid.org/0000-0003-3640-7497)
- Liping Liu (ORCID: https://orcid.org/0000-0002-8679-9567)
- Zhongqian Hu (ORCID: https://orcid.org/0000-0002-8671-5212)
- Hong Ding (ORCID: https://orcid.org/0000-0002-9998-0904)
- Kun Yan (ORCID: https://orcid.org/0000-0001-5841-9857)
- Lijun Wang (ORCID: https://orcid.org/0000-0001-9782-6869)
- Qian Li (ORCID: https://orcid.org/0000-0001-8827-939X)
- Lingling Li (ORCID: https://orcid.org/0000-0002-6130-2518)
- Jianhua Zhou (ORCID: https://orcid.org/0009-0008-9627-6517)
- Wei He (ORCID: https://orcid.org/0000-0001-5801-9044)
- Ho Jae Han (ORCID: https://orcid.org/0000-0002-0657-1766)
- Jingyong Xu
- Jianmin Ding
- Xiaoyan Xie (ORCID: https://orcid.org/0000-0002-3302-8486)
- Ying Huang (ORCID: https://orcid.org/0000-0002-3361-7184)
- Wei Zheng (ORCID: https://orcid.org/0000-0002-6957-7479)
- Zubang Zhou (ORCID: https://orcid.org/0000-0002-2650-4122)
- Wen Cheng (ORCID: https://orcid.org/0000-0002-7231-7635)
- Hai-Tao Ran (ORCID: https://orcid.org/0000-0001-5331-8117)
- Fangyi Liu (ORCID: https://orcid.org/0000-0002-8675-0798)
- Hong Yang (ORCID: https://orcid.org/0000-0001-5586-8999)
- Jie Li (ORCID: https://orcid.org/0000-0001-7142-6197)
- Wen Luo (ORCID: https://orcid.org/0000-0003-1330-4321)
- Yu Hong Li (ORCID: https://orcid.org/0000-0001-6935-6353)
- Bao-Cai Xing (ORCID: https://orcid.org/0000-0002-9854-2726)
- Wenbin Duan
- Baoming Luo
- Jie Ren (ORCID: https://orcid.org/0009-0001-8018-5273)
Institutions
- Harbin Medical University (CN)
- Sun Yat-sen University (CN)
- Guangxi Medical University (CN)
- Shanxi Medical University (CN)
- Shanghai Jiao Tong University (CN)
- Dalian Medical University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Peking University (CN)
- Sichuan University (CN)
- Fudan University (CN)
- China-Japan Friendship Hospital (CN)
- Peking Union Medical College Hospital (CN)
- XinHua Hospital (CN)
- Tianjin Medical University Cancer Institute and Hospital (CN)
- Chinese PLA General Hospital (CN)
- Tianjin Third Central Hospital (CN)
- West China Hospital of Sichuan University (CN)
- Sixth Affiliated Hospital of Sun Yat-sen University (CN)
- Peking University Cancer Hospital (CN)
- Sun Yat-sen Memorial Hospital (CN)
- Second Affiliated Hospital of Chongqing Medical University (CN)
- Zhejiang Cancer Hospital (CN)
- Third Affiliated Hospital of Harbin Medical University (CN)
- ShenZhen People’s Hospital (CN)
- Zhongda Hospital Southeast University (CN)
- Gansu Provincial Hospital (CN)
- Beijing Hospital (CN)
- First Hospital of Shanxi Medical University (CN)
- First Affiliated Hospital of GuangXi Medical University (CN)
- Zhongshan Hospital (CN)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
- Henan Cancer Hospital (CN)
- Shanghai Sixth People's Hospital (CN)
- Sun Yat-sen University Cancer Center (CN)
- Third Affiliated Hospital of Sun Yat-sen University (CN)
- Hunan Provincial People's Hospital (CN)
- Xijing Hospital (CN)
- Huashan Hospital (CN)
- Tongji Hospital (CN)
- Qilu Hospital of Shandong University (CN)
- Huazhong University of Science and Technology (CN)
- Tianjin Medical University (CN)
- Zhejiang University (CN)
- Chongqing Medical University (CN)
- China Medical University (CN)
- Air Force Medical University (CN)
Publication Details
- Journal
- International Journal of Surgery
- Published
- 2025-09-10
- DOI
- https://doi.org/10.1097/js9.0000000000003510
- Primary Topic
- Hepatocellular Carcinoma Treatment and Prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00