Cholinergic G protein‐coupled bile acid receptor 1 (TGR5/GPBA) in the medial septal orchestrates adult hippocampal neurogenesis and cognition in Alzheimer's disease mice
Our findings demonstrate that TGR5 in MS cholinergic neurons is critical during the middle-late stage of AD and provide valuable insights into the underlying neuronal circuit mechanisms. TGR5 (GPBA) represents a potential therapeutic target for AD treatment.
Authors
- Susu Tang (ORCID: https://orcid.org/0000-0003-2316-2523)
- Qilu Zhang (ORCID: https://orcid.org/0000-0001-5706-9250)
- Shan‐Shan Hu
- Yan Long (ORCID: https://orcid.org/0000-0002-9048-4445)
- Hao Hong (ORCID: https://orcid.org/0000-0002-9601-7557)
- Danhua Yuan
- Rui‐Zhe Nie
- Wei‐Kai Jiang
- Xian Cao
- Xinting Zhou
- Xiaojun Tan (ORCID: https://orcid.org/0000-0003-4869-2870)
- Bo‐Wei Guo (ORCID: https://orcid.org/0000-0002-7093-2677)
Institutions
- Nanjing University of Chinese Medicine (CN)
- China Pharmaceutical University (CN)
Publication Details
- Journal
- British Journal of Pharmacology
- Published
- 2025-09-09
- DOI
- https://doi.org/10.1111/bph.70185
- Primary Topic
- Cholinesterase and Neurodegenerative Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00