Routine Doppler Ultrasonography Does Not Differentiate Acute Tubular Necrosis and Rejection in Early Pediatric Kidney Transplantation

RI thresholds and trends do not differentiate ATN and rejection in pediatric KT. Temporal RI rise likely reflects systemic hemodynamic adaptation rather than pathology, limiting its standalone diagnostic utility. Future studies should integrate multimodal approaches with RI, clinical, and biochemical markers to refine noninvasive strategies.

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Publication Details

Journal
Pediatric Transplantation
Published
2025-09-10
DOI
https://doi.org/10.1111/petr.70172
Primary Topic
Renal and Vascular Pathologies
Type
article
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Routine Doppler Ultrasonography Does Not Differentiate Acute Tubular Necrosis and Rejection in Early Pediatric Kidney Transplantation

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1 links
Pediatric Transplantation
Renal and Vascular Pathologies
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Routine Doppler Ultrasonography Does Not Differentiate Acute Tubular Necrosis and Rejection in Early Pediatric Kidney Transplantation

Adree Khondker, Priyank Yadav, Chia Wei Teoh, Armando José Lorenzo, Michael Chua, Ihtisham Ahmad, Ashlene Maree McKay, Dheidan Alshammari, Joana Dos Santos, Nithiakishna Selvathesan, Mandy Rickard, Jin K. Kim
article en

Abstract

RI thresholds and trends do not differentiate ATN and rejection in pediatric KT. Temporal RI rise likely reflects systemic hemodynamic adaptation rather than pathology, limiting its standalone diagnostic utility. Future studies should integrate multimodal approaches with RI, clinical, and biochemical markers to refine noninvasive strategies.

Pediatric TransplantationVol. 29(7)
Sanjay Gandhi Post Graduate Institute of Medical Sciences (IN), University of Toronto (CA), Jahra Hospital (KW), Hospital for Sick Children (CA)
Openalex Percentile: Top 65%
Renal and Vascular Pathologies
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