Germline rare variants in cancer susceptibility genes and subsequent neoplasm risk after childhood cancer
Survivors with rare germline variants in cancer-specific autosomal dominant cancer susceptibility genes had increased subsequent neoplasm risk, especially at younger ages. These findings offer a potential basis for enhancing risk-stratified long-term surveillance for childhood cancer survivors.
Authors
- Lindsay McOmber Morton (ORCID: https://orcid.org/0000-0001-9767-2310)
- Todd M. Gibson (ORCID: https://orcid.org/0000-0002-8718-699X)
- Danielle M. Karyadi (ORCID: https://orcid.org/0000-0003-4164-5625)
- Joshua N. Sampson (ORCID: https://orcid.org/0000-0003-2875-3365)
- Stephen W. Hartley (ORCID: https://orcid.org/0000-0001-6584-005X)
- Peter Kraft (ORCID: https://orcid.org/0000-0002-4472-8103)
- Shahriar A. Zamani (ORCID: https://orcid.org/0000-0001-8622-5013)
- Stephen J. Chanock (ORCID: https://orcid.org/0000-0002-2324-3393)
Institutions
- National Cancer Institute (US)
- Department of Health and Human Services (US)
Publication Details
- Journal
- JNCI Journal of the National Cancer Institute
- Published
- 2025-09-03
- DOI
- https://doi.org/10.1093/jnci/djaf260
- Citations
- 1
- Primary Topic
- DNA Repair Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.81