Acute Pain After Total Knee Arthroplasty: 2-Arachidonoylglycerol Tone and Endocannabinoid/Eicosanoid Crosstalk
Our findings demonstrate that patients presenting with an elevated 2-AG tone develop greater postoperative pain and position MAGL as an enzymatic node linking 2-AG metabolism with eicosanoid biosynthesis in perioperative human tissue.
Authors
- Livia Schutz (ORCID: https://orcid.org/0000-0002-5649-6450)
- James Nicholson
- Alexa Christophides
- Keith M. Studholme (ORCID: https://orcid.org/0000-0002-0037-514X)
- David E. Komatsu (ORCID: https://orcid.org/0000-0002-2618-9492)
- Samuel P. Stanley (ORCID: https://orcid.org/0000-0002-7455-7085)
- Darcy Halper
- Martin Kaczocha (ORCID: https://orcid.org/0000-0002-2527-1398)
- Chris Gordon (ORCID: https://orcid.org/0000-0002-2784-5201)
- Mariam Hassan (ORCID: https://orcid.org/0009-0008-4798-3602)
- Elliott Bennett‐Guerrero (ORCID: https://orcid.org/0000-0001-8659-8098)
- Ayesha Khan (ORCID: https://orcid.org/0000-0002-2661-230X)
Institutions
- Stony Brook School (US)
- Stony Brook University (US)
Publication Details
- Journal
- Anesthesia & Analgesia
- Published
- 2025-09-09
- DOI
- https://doi.org/10.1213/ane.0000000000007741
- Primary Topic
- Cannabis and Cannabinoid Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00