Electrochemical Trifluoromethylation/1,5-HAT Reaction of <i>N</i>-Cyanamide Alkenes: Synthesis of Trifluoromethylated Cyclic Amidines and <i>N</i>-Acryloylpyrrolidin-2-one Derivatives
The electrochemical trifluoromethylation/1,5-HAT of <i>N</i>-cyanamide alkenes with CF<sub>3</sub>SO<sub>2</sub>Na has been achieved to construct trifluoromethylated cyclic amidines and <i>N</i>-acryloylpyrrolidin-2-one derivatives. This transformation was performed with readily available starting materials under mild conditions and required neither oxidants nor transition metal catalysts, exhibiting high atom economy.
Authors
- Zhonglin Wei (ORCID: https://orcid.org/0000-0002-9032-0889)
- Wei‐Wei Liao (ORCID: https://orcid.org/0000-0001-6225-4258)
- Zhihua Yan
- Yan Yan (ORCID: https://orcid.org/0000-0002-1632-4291)
Institutions
- Jilin University (CN)
- Jilin Medical University (CN)
- State Key Laboratory of Inorganic Synthesis and Preparative Chemistry
Publication Details
- Journal
- The Journal of Organic Chemistry
- Published
- 2025-09-09
- DOI
- https://doi.org/10.1021/acs.joc.5c01733
- Primary Topic
- Fluorine in Organic Chemistry
- Type
- article
- Field-Weighted Citation Impact
- 0.00