Obesity is associated with increased brain glucose uptake and activity but not neuroinflammation ( <scp>TSPO</scp> availability) in monozygotic twin pairs discordant for <scp>BMI</scp> —Exercise training reverses increased brain activity
Exercise training had no effect on insulin-stimulated BGU or neuroinflammation (TSPO availability) but it reversed increased resting state brain activity in heavier co-twins. At baseline, obesity was associated with increased insulin-stimulated BGU and resting state brain activity, independent of genetics.
Authors
- Semi Helin (ORCID: https://orcid.org/0000-0002-9405-7301)
- Tarja Malm (ORCID: https://orcid.org/0000-0002-9530-7472)
- Jaakko Hentilä (ORCID: https://orcid.org/0000-0001-8211-8827)
- Jaakko A. Kaprio (ORCID: https://orcid.org/0000-0002-3716-2455)
- Jarna C. Hannukainen (ORCID: https://orcid.org/0000-0002-8692-4049)
- Martin S. Lietzén
- Lauri Nummenmaa (ORCID: https://orcid.org/0000-0002-2497-9757)
- Kalle Koskensalo (ORCID: https://orcid.org/0000-0001-8026-1099)
- Heidi Virtanen (ORCID: https://orcid.org/0000-0002-9335-2712)
- Kirsi Hannele Pietiläinen (ORCID: https://orcid.org/0000-0002-8522-1288)
- Jouni Tuisku (ORCID: https://orcid.org/0000-0003-0965-9365)
- Riikka Läutamaki
- Lihua Sun (ORCID: https://orcid.org/0000-0002-9931-9497)
- Ronja Ojala (ORCID: https://orcid.org/0000-0002-2393-0281)
- Leo Lahti (ORCID: https://orcid.org/0000-0001-5537-637X)
- Eliisa Löyttyniemi
- Juha O. Rinne
Institutions
- University of Helsinki (FI)
- University of Turku (FI)
- University of Eastern Finland (FI)
- Helsinki University Hospital (FI)
- Turku University Hospital (FI)
- Turku PET Centre (FI)
- Institute for Molecular Medicine Finland (FI)
- Huashan Hospital (CN)
Publication Details
- Journal
- Diabetes Obesity and Metabolism
- Published
- 2025-09-10
- DOI
- https://doi.org/10.1111/dom.70109
- Citations
- 1
- Primary Topic
- Cardiovascular Disease and Adiposity
- Type
- article
- Field-Weighted Citation Impact
- 1.39
Funders
- Suomen Kulttuurirahasto
- Turun Yliopisto
- Turun Yliopistollinen Keskussairaala
- Varsinais-Suomen Rahasto