The Efficacy and Safety of Teprotumumab in Geriatrics Patients: A Multicenter Study
Teprotumumab is effective in reducing clinical activity score and proptosis in geriatric thyroid eye disease patients with short-term follow-up; however, high rates of adverse events, reactivation, and proptosis regression over time warrant extreme caution and selective use in this population.
Authors
- Madhura A. Tamhankar (ORCID: https://orcid.org/0000-0002-1745-0994)
- Andrea L. Kossler (ORCID: https://orcid.org/0000-0003-3110-1210)
- Kimberly Cockerham
- Sara Tullis Wester (ORCID: https://orcid.org/0000-0002-7289-0853)
- Rafael Rubio (ORCID: https://orcid.org/0000-0001-8132-4303)
- Amina Malik
- Benyam Kinde (ORCID: https://orcid.org/0000-0003-0867-1282)
- Patcharaporn Chandraparnik (ORCID: https://orcid.org/0009-0009-1382-4387)
- Evan Meyer
- Andrew R. Harrison (ORCID: https://orcid.org/0000-0003-4005-2772)
- Taylor Linaburg (ORCID: https://orcid.org/0000-0003-1855-5947)
- Connie M. Sears (ORCID: https://orcid.org/0000-0003-0727-8198)
- Linus Amarikwa (ORCID: https://orcid.org/0000-0002-0331-5660)
- Ridhima Guniganti
- Melissa Goldin
- Roman Shinder
- Daniel B. Rootman (ORCID: https://orcid.org/0000-0001-6911-1292)
- Hannah Walsh (ORCID: https://orcid.org/0000-0002-4591-5971)
- Louise A. Mawn (ORCID: https://orcid.org/0000-0001-5123-7495)
- Chrysoula Dosiou (ORCID: https://orcid.org/0000-0001-6609-5135)
- Shreya Shah (ORCID: https://orcid.org/0000-0001-7055-7566)
- Steven M. Couch
- Suyoung Choi (ORCID: https://orcid.org/0000-0002-7474-610X)
- Karmouta Reem
Institutions
- Barnes-Jewish Hospital (US)
- University of Minnesota (US)
- SUNY Downstate Health Sciences University (US)
- Vanderbilt University (US)
- Phramongkutklao Hospital (TH)
- Methodist Hospital (US)
- Doheny Eye Institute (US)
- Jewish Hospital (US)
- Smith-Kettlewell Eye Research Institute (US)
- Phramongkutklao College of Medicine
- University of Nebraska Medical Center (US)
- University of Pennsylvania (US)
- Stanford University (US)
Publication Details
- Journal
- Ophthalmic Plastic and Reconstructive Surgery
- Published
- 2025-09-09
- DOI
- https://doi.org/10.1097/iop.0000000000003024
- Citations
- 1
- Primary Topic
- Ophthalmology and Eye Disorders
- Type
- article
- Field-Weighted Citation Impact
- 1.47