Integrative network toxicology and molecular docking reveal 4-Nonylphenol’s multifaceted mechanisms in breast cancer pathogenesis
Our study demonstrates that 4-NP exposure perturbs protein conformational of hub targets, activating cascades and dysregulating signaling pathway to potentiate breast cancer risk. Furthermore, we identify a novel miRNA-mediated regulatory axis alongside MAPK signaling as critical mechanisms underpinning 4-NP toxicity.
Authors
- Congli Jia (ORCID: https://orcid.org/0000-0002-7090-6364)
- Yang Fu
Institutions
- Weifang Medical University (CN)
- Kunming Medical University (CN)
- Second Hospital of Shandong University (CN)
- First Affiliated Hospital of Kunming Medical University (CN)
Publication Details
- Journal
- PLoS ONE
- Published
- 2025-09-09
- DOI
- https://doi.org/10.1371/journal.pone.0331944
- Primary Topic
- Computational Drug Discovery Methods
- Type
- article
- Field-Weighted Citation Impact
- 0.00