Na-Cl Cotransporter (<i>SLC12A3</i>) Inhibition Exacerbates Age-Related Macular Degeneration Via the Nrf2/HO-1 Ferroptosis Pathway
Our study underscores a notable causal association between thiazide diuretic use and AMD risk and reveals a potential mechanism by which inhibition or downregulation of SLC12A3 (sodium-chloride cotransporter [NCC]) contributes to AMD progression. However, deeper exploration is needed to enhance the accuracy and validity of our findings.
Authors
- Chengming Chen (ORCID: https://orcid.org/0000-0001-5684-1675)
- Sida Liu (ORCID: https://orcid.org/0000-0003-2335-8630)
- Dongyu Wei (ORCID: https://orcid.org/0009-0009-8167-6435)
- Chao Fan (ORCID: https://orcid.org/0000-0003-1657-3922)
- Lei Shang (ORCID: https://orcid.org/0000-0003-0470-0066)
- Lifu Chang
- Xiaolong Yan (ORCID: https://orcid.org/0000-0003-2419-9707)
- Huan Zhang (ORCID: https://orcid.org/0000-0001-9512-4492)
- Liyuan Tao (ORCID: https://orcid.org/0000-0003-3497-1326)
- Yuhao Chen (ORCID: https://orcid.org/0000-0001-8855-5542)
- Yixuan Chen (ORCID: https://orcid.org/0000-0001-7390-0622)
- Tingke Xie
- Yanyan Lan (ORCID: https://orcid.org/0000-0002-7811-3262)
- Jing Han (ORCID: https://orcid.org/0000-0003-2584-443X)
- Xiaolan Wang (ORCID: https://orcid.org/0009-0005-0703-7134)
- Xuejiao Wang (ORCID: https://orcid.org/0009-0002-1253-5304)
Institutions
- Fujian University of Traditional Chinese Medicine (CN)
- Fujian Medical University (CN)
- Peking University (CN)
- Peking University Third Hospital (CN)
- Air Force Medical University (CN)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2025-09-10
- DOI
- https://doi.org/10.1167/iovs.66.12.24
- Citations
- 1
- Primary Topic
- Retinal Diseases and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.71