Expression of cluster of differentiation 47 (CD47) and signal regulatory protein alpha (SIRPα) as prognostic biomarkers and potentially therapeutic targets in esophageal squamous cell carcinoma
Overexpression of SIRPα and CD47, especially in tandem, is associated with poor clinical outcomes in ESCC, suggesting that the CD47-SIRPα axis may serve as a useful prognostic biomarker and a potential therapeutic target for newly immune checkpoint blockade in ESCC.
Authors
- Yohei Ozawa (ORCID: https://orcid.org/0000-0002-5136-8281)
- Kaiyuan Jiang (ORCID: https://orcid.org/0000-0002-8212-1011)
- Takashi Kamei (ORCID: https://orcid.org/0000-0003-1282-0463)
- Hirotaka Ishida (ORCID: https://orcid.org/0000-0002-6814-3564)
- Junpeng Li (ORCID: https://orcid.org/0000-0002-2170-8230)
- Shinobu Ohnuma (ORCID: https://orcid.org/0000-0002-0205-8957)
- Michiaki Unno (ORCID: https://orcid.org/0000-0002-2145-6416)
- Chiaki Sato (ORCID: https://orcid.org/0000-0002-0810-0300)
- Yusuke Taniyama (ORCID: https://orcid.org/0000-0003-2563-247X)
- Naoto Ujiie (ORCID: https://orcid.org/0000-0001-9431-0912)
- Takeru Mozumi
- Hiroshi Okamoto (ORCID: https://orcid.org/0000-0002-9042-7096)
Institutions
- Tohoku University (JP)
Publication Details
- Journal
- Esophagus
- Published
- 2025-09-10
- DOI
- https://doi.org/10.1007/s10388-025-01152-5
- Primary Topic
- Phagocytosis and Immune Regulation
- Type
- article
- Field-Weighted Citation Impact
- 0.00