Mitochondrial transfer from adipose-derived regenerative cells contributes therapeutic angiogenesis in a murine hindlimb ischemia model
ADRCs can protect against ischemic limbs, at least in part by mitochondrial transfer via gap junctions and tunneling of nanotubes into injured endothelial cells and macrophages. Additionally, mitochondrial transfer is a potential mechanism for therapeutic angiogenesis with ADRCs in hindlimb ischemia.
Authors
- Kazuhito Tsuzuki
- Takumi Hayashi
- Shingo Narita (ORCID: https://orcid.org/0000-0001-5493-136X)
- Yoshimitsu Yura (ORCID: https://orcid.org/0000-0003-2618-8569)
- Toyoaki Murohara (ORCID: https://orcid.org/0000-0003-2723-6243)
- Yuuki Shimizu (ORCID: https://orcid.org/0000-0003-3103-1160)
- Yiyang Che
- Zhongyue Pu (ORCID: https://orcid.org/0000-0001-9619-0571)
- Rei Shibata (ORCID: https://orcid.org/0000-0003-4179-8453)
- Junya Suzuki (ORCID: https://orcid.org/0000-0002-8115-6837)
Institutions
- Nagoya University (JP)
Publication Details
- Journal
- Angiogenesis
- Published
- 2025-09-10
- DOI
- https://doi.org/10.1007/s10456-025-10001-z
- Citations
- 2
- Primary Topic
- Mesenchymal stem cell research
- Type
- article
- Field-Weighted Citation Impact
- 3.25