Virulence factors and outcomes in bacteremia caused by extended-spectrum β-lactamase-producing uropathogenic Escherichia coli ST131-H30Rx in a Swedish county
ST131-H30Rx isolates carried VFs which were associated with recurrence but not uniformly to sepsis. In this explorative study, our results indicate that the ST131-H30Rx clade are not more prone to cause severe infection than other sequence types, but prone to cause recurrence, in addition to ESBL production which limits treatment options. Further studies are warranted to explore the mechanisms driving the success of ST131-H30Rx isolates in causing recurrent infections and colonization, and to form preventive measures.
Authors
- Håkan Hanberger (ORCID: https://orcid.org/0000-0002-4199-0229)
- Åse Östholm Balkhed (ORCID: https://orcid.org/0000-0002-8250-8785)
- Mindie H. Nguyen (ORCID: https://orcid.org/0000-0002-6275-4989)
- Martin Holmbom (ORCID: https://orcid.org/0000-0002-3706-2294)
- Jenny Welander
- Vidar Möller
- Lennart E. Nilsson (ORCID: https://orcid.org/0000-0002-4104-4195)
- Maud Nilsson
- Björn Berglund
Institutions
- Linköping University (SE)
- Uppsala University (SE)
- Science for Life Laboratory (SE)
- Linköping University Hospital (SE)
- KTH Royal Institute of Technology (SE)
Publication Details
- Journal
- BMC Infectious Diseases
- Published
- 2025-09-08
- DOI
- https://doi.org/10.1186/s12879-025-11519-9
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Forskningsrådet i Sydöstra Sverige
- Linköpings Universitet
- Vetenskapsrådet