Brain network signatures of spatial memory in adolescents at risk for substance use
Adolescents who later initiated substance use showed distinct baseline network patterns in systems supporting spatial memory and attention (DAN) and task control and salience detection (SN). In contrast, hippocampal network activation (MTL-DMN) was not evident before initiation but may emerge later as a consequence of use. Because substance use status was categorized for group comparisons, early variability may not be fully captured. These findings underscore the need for future longitudinal analyses to disentangle neurobiological markers of risk that precede adolescent substance use from alterations that arise as a result of use.
Authors
- Anna M. Seraikas
- Eleanor M. Schuttenberg
- Poornima Kumar (ORCID: https://orcid.org/0000-0002-9548-3281)
- Lisa D. H. Nickerson (ORCID: https://orcid.org/0000-0002-9623-6688)
- Emily N. Oot (ORCID: https://orcid.org/0000-0001-6907-3257)
- Sion Kim Harris (ORCID: https://orcid.org/0000-0002-4618-0348)
- Marisa M. Silveri (ORCID: https://orcid.org/0000-0001-9668-8548)
- Derek A. Hamilton (ORCID: https://orcid.org/0000-0001-7021-3288)
- Jennifer T. Sneider (ORCID: https://orcid.org/0000-0003-3850-8400)
- Helen R. Sabolek
- Julia E. Cohen‐Gilbert (ORCID: https://orcid.org/0000-0002-4975-3500)
- Andie Stallman
Institutions
- Regis College (US)
- Boston University (US)
- Boston Children's Hospital (US)
- Harvard University (US)
- University of New Mexico (US)
- McLean Hospital (US)
Publication Details
- Journal
- Alcohol Clinical and Experimental Research
- Published
- 2025-09-09
- DOI
- https://doi.org/10.1111/acer.70155
- Citations
- 1
- Primary Topic
- Functional Brain Connectivity Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.43