Novel Prognostic Scoring Systems for Severe CRS after Anti-CD19 CAR-T-Cells in Acute B-Lymphoblastic Leukemia
This study developed a novel prognostic scoring system for severe CRS in Chinese B-ALL patients receiving anti-CD19 CAR-T-cell therapy. The model integrates clinical and laboratory parameters to facilitate early identification and management of severe CRS. Further validation in larger, prospective cohorts is warranted.
Authors
- Mengyi Du (ORCID: https://orcid.org/0000-0003-2428-352X)
- Ke Sha (ORCID: https://orcid.org/0000-0002-9024-3633)
- Tao� Zhang (ORCID: https://orcid.org/0000-0003-4018-3393)
- Lin Liu (ORCID: https://orcid.org/0000-0001-9690-1302)
- Zhuolin Wu (ORCID: https://orcid.org/0000-0002-8938-894X)
- Wei Xie (ORCID: https://orcid.org/0000-0002-4358-3950)
Institutions
- Union Hospital (HK)
- Wuhan Union Hospital (CN)
- Shanghai Cell Therapy Research Institute (CN)
- Hubei Cancer Hospital (CN)
- Union Hospital (CN)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- Current Medical Science
- Published
- 2025-09-10
- DOI
- https://doi.org/10.1007/s11596-025-00109-0
- Citations
- 1
- Primary Topic
- CAR-T cell therapy research
- Type
- article
- Field-Weighted Citation Impact
- 1.05
Funders
- National Natural Science Foundation of China