Significance of Th1 and Th2 Cell Densities and Th1/Th2 Cytokine Profiles in Colorectal Cancer
Findings highlight comparable roles for Th1 and Th2 cells in predicting favorable outcome and challenge the traditional notion of Th2 cells as tumor promoters.
Authors
- Maarit Ahtiainen (ORCID: https://orcid.org/0000-0002-3263-2307)
- Hanna Elomaa (ORCID: https://orcid.org/0000-0002-5378-7703)
- Ville K. Äijälä (ORCID: https://orcid.org/0009-0005-7664-8027)
- Juha Saarnio (ORCID: https://orcid.org/0000-0002-8443-3625)
- Olli Helminen (ORCID: https://orcid.org/0000-0001-9544-6475)
- Tero Rautio (ORCID: https://orcid.org/0000-0003-4441-9412)
- Jan Böhm (ORCID: https://orcid.org/0000-0001-9664-588X)
- Erkki‐Ville Wirta (ORCID: https://orcid.org/0000-0002-2255-6136)
- Toni T. Seppälä (ORCID: https://orcid.org/0000-0002-4940-3498)
- Meeri Kastinen (ORCID: https://orcid.org/0009-0007-0954-5612)
- Markus J. Mäkinen (ORCID: https://orcid.org/0000-0002-9200-4118)
- Päivi Sirniö (ORCID: https://orcid.org/0000-0002-3988-3782)
- Vesa‐Matti Pohjanen (ORCID: https://orcid.org/0000-0002-4129-4346)
- Jukka‐Pekka Mecklin (ORCID: https://orcid.org/0000-0003-4895-2249)
- Raila Aro (ORCID: https://orcid.org/0000-0001-8193-8460)
- Reetta Häivälä (ORCID: https://orcid.org/0009-0001-4537-1214)
- Henna Karjalainen (ORCID: https://orcid.org/0009-0008-4694-6703)
- Jukka M. J. Rintala (ORCID: https://orcid.org/0000-0003-1865-8444)
- Juha P. Väyrynen (ORCID: https://orcid.org/0000-0002-8683-2996)
- Anne Tuomisto (ORCID: https://orcid.org/0000-0002-9949-1887)
- Vilja V. Tapiainen (ORCID: https://orcid.org/0009-0003-6306-6525)
- Sanna Meriläinen (ORCID: https://orcid.org/0000-0002-5418-4373)
- Akseli Kehusmaa (ORCID: https://orcid.org/0009-0004-9415-7283)
- Aino Ojanperä (ORCID: https://orcid.org/0009-0000-9399-2253)
- Oskari Rahkola (ORCID: https://orcid.org/0009-0004-0865-3302)
Institutions
- University of Helsinki (FI)
- Oulu University Hospital (FI)
- Helsinki University Hospital (FI)
- Tampere University Hospital (FI)
- Tampere University (FI)
- Central Finland Health Care District (FI)
- University of Jyväskylä (FI)
Publication Details
- Journal
- Cancer Epidemiology Biomarkers & Prevention
- Published
- 2025-08-14
- DOI
- https://doi.org/10.1158/1055-9965.epi-25-0767
- Citations
- 2
- Primary Topic
- Immune Cell Function and Interaction
- Type
- article
- Field-Weighted Citation Impact
- 1.59