Circulating Tumor DNA Profiling Identifies Actionable Mutations as Prognostic Markers in Advanced Neuroendocrine Tumors
We constructed an overview of mutations in 37 genes, linking ctDNA to survival in advanced NETs. TERT mutations, bTMB, and MSAF predict PFS or OS. Co-occurring TM, mTOR, and NOTCH pathway alterations highlight ctDNA's potential in guiding precision medicine. .
Authors
- Yang Gao (ORCID: https://orcid.org/0000-0002-2875-618X)
- Chunmei Bai (ORCID: https://orcid.org/0000-0003-1333-9145)
- Hongyan Ying
- Mei Guan (ORCID: https://orcid.org/0000-0001-5929-7142)
- Yuejuan Cheng (ORCID: https://orcid.org/0000-0003-4491-2370)
- Jiazhang Xing (ORCID: https://orcid.org/0000-0002-5430-5497)
- Huanwen Wu (ORCID: https://orcid.org/0000-0002-3996-3176)
- Na Zhou (ORCID: https://orcid.org/0000-0002-3808-1323)
- Guofeng Zhao (ORCID: https://orcid.org/0009-0005-0710-2979)
- Lin Zhao (ORCID: https://orcid.org/0000-0003-1700-9549)
- Mingying Wu (ORCID: https://orcid.org/0009-0004-8446-3316)
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Peking Union Medical College Hospital (CN)
- University of California San Diego (US)
- Zhejiang University (CN)
Publication Details
- Journal
- Neuroendocrinology
- Published
- 2025-09-09
- DOI
- https://doi.org/10.1159/000548256
- Primary Topic
- Neuroendocrine Tumor Research Advances
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Chinese Academy of Medical Sciences
- Peking Union Medical College Hospital