[Vitiligo].

Vitiligo is a chronic skin disease characterized by white patches caused by the destruction of melanocytes. The most well-known variant is non-segmental vitiligo, where patches are symmetrically distributed across the entire body, with alternating periods of stability and progression. The white patches arise due to an autoimmune reaction in which cytotoxic T-cells attack the melanocytes. Treatment aims to halt the progression and to achieve repigmentation of existing lesions. The treatment often consists of a combination of topical therapy and phototherapy, sometimes supplemented by systemic corticosteroids or surgical techniques. However, recently new treatments have entered the market, notably treatment with JAK inhibitors (both topical and systemic), with promising results.

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Publication Details

Journal
PubMed
Published
2025-09-08
Primary Topic
melanin and skin pigmentation
Type
article
Field-Weighted Citation Impact
0.00
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article

[Vitiligo].

Albert Wolkerstorfer, P. M. J. H. Kemperman, Marcel W. Bekkenk, S.E. Uitentuis
PubMed
melanin and skin pigmentation
article

[Vitiligo].

Albert Wolkerstorfer, P. M. J. H. Kemperman, Marcel W. Bekkenk, S.E. Uitentuis
article en

Abstract

Vitiligo is a chronic skin disease characterized by white patches caused by the destruction of melanocytes. The most well-known variant is non-segmental vitiligo, where patches are symmetrically distributed across the entire body, with alternating periods of stability and progression. The white patches arise due to an autoimmune reaction in which cytotoxic T-cells attack the melanocytes. Treatment aims to halt the progression and to achieve repigmentation of existing lesions. The treatment often consists of a combination of topical therapy and phototherapy, sometimes supplemented by systemic corticosteroids or surgical techniques. However, recently new treatments have entered the market, notably treatment with JAK inhibitors (both topical and systemic), with promising results.

PubMedVol. 169
Dutch Centre for Field Ornithology (NL), Phoenix Contact (United States) (US)
Openalex Percentile: Top 74%
melanin and skin pigmentation
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