Prolonged in vitro anti-bacterial, anti-inflammatory, and surfactant-promoting effects of volatile anesthetics
Prolonged anti-bacterial and anti-inflammatory effects of Sevoflurane and Desflurane include both the reduction of Pseudomonas aeruginosa and Staphylococcus aureus growth as well as the inhibition of LPS-induced chemokine release by A549 epithelial cells paralleled by an increase of surfactant protein expression. These effects highlight the potential of volatile anesthetics beyond sedation in supporting lung function in ventilated patients with respiratory failure.
Authors
- Cordula Stamme
- Rolf Brinkmann
- Claudia Scheffzük (ORCID: https://orcid.org/0000-0002-9412-843X)
- Dominika Biedziak
- Patrick Kellner (ORCID: https://orcid.org/0000-0001-6274-3529)
- Johanna Lührmann
- Kristina Gloystein
Institutions
- DIAKO (DE)
- University Hospital Schleswig-Holstein (DE)
- Research Center Borstel - Leibniz Lung Center (DE)
- BG University Hospital Bergmannsheil Bochum (DE)
- Segeberger Kliniken (DE)
- Jewish Hospital (US)
- University of Lübeck (DE)
Publication Details
- Journal
- BMC Pulmonary Medicine
- Published
- 2025-09-09
- DOI
- https://doi.org/10.1186/s12890-025-03849-w
- Primary Topic
- Respiratory Support and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Deutsche Forschungsgemeinschaft