Exploring the limits of exercise capacity in adults with type II diabetes
Cardiac output is the primary determinant of exercise capacity in adults with T2DM. This suggests that muscle perfusion may be the main limiting factor in relatively fit individuals with T2DM. However, cardiac output and local muscle perfusion are not directly equivalent, as mechanical factors, such as intramuscular pressure during high-intensity exercise, may prevent maximal perfusion.
Authors
- Kaatje Goetschalckx (ORCID: https://orcid.org/0000-0002-5419-7684)
- Panagiotis N. Chatzinikolaou (ORCID: https://orcid.org/0000-0002-8136-1638)
- Marieke De Craemer (ORCID: https://orcid.org/0000-0002-5220-7850)
- Camille De Wilde (ORCID: https://orcid.org/0000-0003-0498-8012)
- Youri Bekhuis (ORCID: https://orcid.org/0000-0003-3903-5051)
- Dominique Hansen (ORCID: https://orcid.org/0000-0003-3074-2737)
- Matthijs Michielsen (ORCID: https://orcid.org/0000-0001-9816-7359)
- Guido Claessen (ORCID: https://orcid.org/0000-0001-8261-6666)
- Tin Gojevic (ORCID: https://orcid.org/0000-0002-2893-8629)
- Véronique Cornelissen (ORCID: https://orcid.org/0000-0002-0578-4954)
- Jomme Claes (ORCID: https://orcid.org/0000-0003-3922-0038)
- Elise Decorte
- Daphni Daraki
- Eleftheria Kounalaki
- Louise Costalunga
- Sara Amyay
- Varvara Lazarou
Institutions
- Aristotle University of Thessaloniki (GR)
- Universitair Ziekenhuis Leuven (BE)
- Ghent University (BE)
- Jessa Hospital (BE)
- Hasselt University (BE)
- KU Leuven (BE)
Publication Details
- Journal
- PLoS ONE
- Published
- 2025-09-09
- DOI
- https://doi.org/10.1371/journal.pone.0331737
- Citations
- 2
- Primary Topic
- Cardiovascular and exercise physiology
- Type
- article
- Field-Weighted Citation Impact
- 4.76
Funders
- Fonds Wetenschappelijk Onderzoek
- Vlaamse regering