Intestinal epithelial Dicer1 regulates gut microbiome and Alzheimer’s pathology in App-knock-in mice
Deletion of Dicer1 in intestinal epithelial cells modulates the microbiome in both the gut and brain, and AD pathologies in the brain of App-knock-in mice. Future studies should focus on the identification of AD-specific miRNAs in the gut that can be therapeutically utilized to alter the gut microbiome and prevent AD progression.
Authors
- Gilles Gasparoni (ORCID: https://orcid.org/0000-0002-6423-4637)
- Wenqiang Quan (ORCID: https://orcid.org/0000-0002-8243-8078)
- Hsin‐Fang Chang (ORCID: https://orcid.org/0000-0002-7691-4090)
- Qinghua Luo (ORCID: https://orcid.org/0000-0003-2828-1118)
- Julia M. Schulze‐Hentrich (ORCID: https://orcid.org/0000-0002-9242-2096)
- Sascha Tierling (ORCID: https://orcid.org/0000-0001-9211-5291)
- I Szabó (ORCID: https://orcid.org/0000-0002-2607-5305)
- Wenlin Hao (ORCID: https://orcid.org/0009-0001-9855-1518)
- Yang Liu (ORCID: https://orcid.org/0000-0002-7614-4233)
- Gang Wu (ORCID: https://orcid.org/0009-0007-6537-2285)
Institutions
- Tongji University (CN)
- Nanchang University (CN)
- Wenzhou Medical University (CN)
- Second Affiliated Hospital of Nanchang University (CN)
- Zhejiang Taizhou Hospital (CN)
- Tongji Hospital (CN)
- Saarland University (DE)
Publication Details
- Journal
- Alzheimer s Research & Therapy
- Published
- 2025-09-09
- DOI
- https://doi.org/10.1186/s13195-025-01849-w
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 0.00