Multiomics Comparison of Proline‐Rich Peptide‐Enhanced Hyaluronic Acid Gels Versus Conventional Regenerative Materials: An Early Wound‐Healing Model
HA + P6 suppressed TNF-α and trypsin signalling while boosting M2-linked markers and proresolution proteins to the same extent as EMD, whereas plain HA did not. Thus, adding a short proline-rich peptide confers EMD-like early immunomodulation on a fully synthetic HA carrier. These observations, although limited to 6-day soft tissue healing, warrant longer studies in true periodontal regeneration models.
Authors
- Håvard Jostein Haugen (ORCID: https://orcid.org/0000-0002-6690-7233)
- Thaqif El Khassawna (ORCID: https://orcid.org/0000-0002-1187-8578)
- Ståle Petter Lyngstadaas (ORCID: https://orcid.org/0000-0002-6361-7644)
- María Permuy
- Fernando Muñóz (ORCID: https://orcid.org/0000-0002-4130-1526)
- Reem Jamous
- Marta Monjo (ORCID: https://orcid.org/0000-0002-2731-9527)
- Joana Maria Ramis (ORCID: https://orcid.org/0000-0001-9109-8362)
- Antonio González‐Cantalapiedra (ORCID: https://orcid.org/0000-0002-8586-956X)
- Filippo Rossi (ORCID: https://orcid.org/0000-0003-2665-120X)
- Øystein Øvrebø (ORCID: https://orcid.org/0000-0001-9170-0202)
- Qianli Ma (ORCID: https://orcid.org/0000-0002-7044-8172)
- Antonio José Serrano‐Muñoz (ORCID: https://orcid.org/0009-0005-7867-8940)
Institutions
- University of Jordan (JO)
- Synlab Czech (Czechia) (CZ)
- Bayer (Norway) (NO)
- University of Oslo (NO)
- Universidade de Santiago de Compostela (ES)
- Justus-Liebig-Universität Gießen (DE)
- Health Research Institute of the Balearic Islands (ES)
- Research Institute of Health Sciences (ES)
- Politecnico di Milano (IT)
Publication Details
- Journal
- Journal of Periodontal Research
- Published
- 2025-09-10
- DOI
- https://doi.org/10.1111/jre.70032
- Citations
- 2
- Primary Topic
- Periodontal Regeneration and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 3.67
Funders
- European Commission
- Universitetet i Oslo
- Norges Forskningsråd
- Eurostars