Efficacious suppression of primary and metastasized liver tumors by polyIC-loaded lipid nanoparticles
Contrary to our original goal, we unexpectedly found that polyIC-LNPs function as an efficacious monotherapy tailored for liver cancer, capable of coordinately modulating antitumor immunity. This novel approach eliminates the need for ICIs, thereby addressing key limitations of current immunotherapies.
Authors
- Peter D. Adams (ORCID: https://orcid.org/0000-0002-0684-1770)
- Tzu‐Chun Hsiao (ORCID: https://orcid.org/0000-0001-6435-2214)
- Gen‐Sheng Feng (ORCID: https://orcid.org/0000-0003-1255-4708)
- Nishta Krishnan
- Marcos G. Teneche (ORCID: https://orcid.org/0000-0003-4785-7987)
- Yingluo Liu (ORCID: https://orcid.org/0009-0009-5704-063X)
- Elina I. Zúñiga (ORCID: https://orcid.org/0000-0001-8699-1623)
- Yichun Ji (ORCID: https://orcid.org/0000-0001-8313-1871)
- Kota Kaneko (ORCID: https://orcid.org/0009-0001-8595-8220)
- Liangfang Zhang (ORCID: https://orcid.org/0000-0003-0637-0654)
- Xinyi Wang (ORCID: https://orcid.org/0000-0002-6926-5934)
- Susan M. Kaech (ORCID: https://orcid.org/0000-0001-5156-6635)
Institutions
- Salk Institute for Biological Studies (US)
- Sanford Burnham Prebys Medical Discovery Institute (US)
- Discovery Institute (US)
- University of California San Diego (US)
- La Jolla Institute For Molecular Medicine (US)
Publication Details
- Journal
- Hepatology
- Published
- 2025-09-10
- DOI
- https://doi.org/10.1097/hep.0000000000001514
- Citations
- 2
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 2.09