Eco Friendly and Budget Smart: An Economic and Environmental Evaluation of Alternative PD-1 and PD-L1 Inhibitor Dosing Regimens
These findings suggest that optimizing dosing strategies can yield meaningful economic and environmental benefits in ICI therapy while maintaining drug exposure within levels defined by US Food and Drug Administration criteria or broader therapeutic windows. A user-friendly application developed in this study allows users to generate virtual populations and evaluate tailored dosing strategies, facilitating practical implementation in diverse healthcare settings.
Authors
- Rob ter Heine (ORCID: https://orcid.org/0000-0003-2185-8201)
- Maddalena Centanni (ORCID: https://orcid.org/0000-0001-6594-9813)
- Lisbeth Karlsson (ORCID: https://orcid.org/0009-0009-4880-6496)
- Joseph Ciccolini (ORCID: https://orcid.org/0000-0003-1733-3410)
Institutions
- Uppsala University (SE)
- Radboud University Nijmegen (NL)
- Inserm (FR)
- Radboud University Medical Center (NL)
- Centre de Recherche en Cancérologie de Marseille (FR)
Publication Details
- Journal
- PharmacoEconomics
- Published
- 2025-09-10
- DOI
- https://doi.org/10.1007/s40273-025-01535-7
- Citations
- 1
- Primary Topic
- Economic and Financial Impacts of Cancer
- Type
- article
- Field-Weighted Citation Impact
- 3.13
Funders
- Cancerfonden
- Uppsala Universitet