Targeting G9a decreases escalated alcohol drinking in male mice in a model of combined stress and chronic alcohol exposure
These preclinical data suggest that reducing NAc G9a levels, or suppressing its enzymatic activity, can effectively reduce potentiated alcohol drinking produced by stress and/or alcohol dependence. These data suggest that G9a inhibition holds promise as a potential therapeutic for individuals who suffer from AUD.
Authors
- Christopher W. Cowan (ORCID: https://orcid.org/0000-0001-5472-3296)
- Howard C. Becker (ORCID: https://orcid.org/0000-0001-8042-6957)
- Paulina Misztak (ORCID: https://orcid.org/0000-0002-7232-3162)
- Marcelo F. Lopez (ORCID: https://orcid.org/0000-0001-5885-7371)
- Ethan M. Anderson (ORCID: https://orcid.org/0000-0002-4021-6741)
Institutions
- Louisiana State University (US)
- Medical University of South Carolina (US)
- TiGenix (Spain) (ES)
- Ralph H. Johnson VA Medical Center (US)
Publication Details
- Journal
- Alcohol Clinical and Experimental Research
- Published
- 2025-09-09
- DOI
- https://doi.org/10.1111/acer.70142
- Citations
- 1
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- National Institutes of Health