Association of preoperative cerebrospinal fluid sTREM2 concentration with postoperative delirium and 3-year mortality in patients total knee or hip arthroplasty: a prospective cohort study
Elevated CSF sTREM2 is a preoperative risk factor for POD, which is partially mediated by tau and ptau. The CatBoost model can accurately predict the occurrence of POD. Age≥80 plus sTREM2 ≥ 20 000 pg/ml could increase 3-year mortality in POD cases.
Authors
- Shanling Xu (ORCID: https://orcid.org/0000-0002-1801-1440)
- Hongyan Gong
- Jiahan Wang (ORCID: https://orcid.org/0009-0006-5115-6939)
- Yun-Chao Yang
- Lin Xu (ORCID: https://orcid.org/0000-0002-0537-922X)
- Bin Wang (ORCID: https://orcid.org/0000-0002-6159-5242)
- Xiao Wang (ORCID: https://orcid.org/0000-0002-5893-5162)
- Yizhi Liang (ORCID: https://orcid.org/0000-0002-7475-496X)
- Yanan Lin
- Yanlin Bi (ORCID: https://orcid.org/0000-0002-9006-976X)
- Chuan Li (ORCID: https://orcid.org/0000-0001-8098-1715)
- Shuhui Hua
- Jian Kong (ORCID: https://orcid.org/0000-0002-5936-1041)
Institutions
- Qingdao University (CN)
- Weifang Medical University (CN)
- Shandong University of Aeronautics (CN)
- Qingdao Municipal Hospital (CN)
Publication Details
- Journal
- International Journal of Surgery
- Published
- 2025-09-10
- DOI
- https://doi.org/10.1097/js9.0000000000003465
- Citations
- 1
- Primary Topic
- Intensive Care Unit Cognitive Disorders
- Type
- article
- Field-Weighted Citation Impact
- 1.55