Indirect treatment comparison of two pulsed field ablation systems for the treatment of persistent atrial fibrillation

PFA is generally safe and efficient; however, in this ITC, SPHERE Per-AF showed a higher probability of treatment success in PerAF patients compared to ADVANTAGE AF. Overall, these results underline possible differences even amongst PFA systems, which must be validated in randomized trials. Until then, MAIC methods fill the current evidence gap. Registry and the Registration No. SPHERE Per-AF: NCT05120193 and ADVANTAGE AF: NCT05443594.

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Publication Details

Journal
Journal of Interventional Cardiac Electrophysiology
Published
2025-09-10
DOI
https://doi.org/10.1007/s10840-025-02124-6
Primary Topic
Atrial Fibrillation Management and Outcomes
Type
article
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article

Indirect treatment comparison of two pulsed field ablation systems for the treatment of persistent atrial fibrillation

Kazuo Matsumoto, Kelly A. van Bragt, Waruiru Mburu, Fred Kueffer et al.
Journal of Interventional Cardiac Electrophysiology
Atrial Fibrillation Management and Outcomes
article

Indirect treatment comparison of two pulsed field ablation systems for the treatment of persistent atrial fibrillation

Kazuo Matsumoto, Kelly A. van Bragt, Waruiru Mburu, Fred Kueffer, Khaldoun G. Tarakji
article en

Abstract

PFA is generally safe and efficient; however, in this ITC, SPHERE Per-AF showed a higher probability of treatment success in PerAF patients compared to ADVANTAGE AF. Overall, these results underline possible differences even amongst PFA systems, which must be validated in randomized trials. Until then, MAIC methods fill the current evidence gap. Registry and the Registration No. SPHERE Per-AF: NCT05120193 and ADVANTAGE AF: NCT05443594.

Journal of Interventional Cardiac ElectrophysiologyVol. 69(3)
Medtronic (Ireland) (IE), Medtronic (United States) (US), Saitama Medical University Hospital (JP), Saiseikai Matsuyama Hospital (JP), Medtronic (Germany) (DE)
Openalex Percentile: Top 63%
Atrial Fibrillation Management and Outcomes
DOIOpen Access PDFOpenAlex
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Indirect treatment comparison of two pulsed field ablation systems for the treatment of persistent atrial fibrillation — Kazuo Matsumoto, Kelly A. van Bragt, et al. · Journal of Interventional Cardiac Electrophysiology (2025) | TGRS Research Map | TGRS