Photosensitized Radical-Mediated 1,<i>n</i>-Trifluoromethylthioamination of Alkenes with Bifunctional Benzophenonoxime <i>S</i>-(Trifluoromethyl) Thiocarbonate
Herein, we report that a novel and efficient bifunctional reagent, benzophenonoxime <i>S</i>-(CF<sub>3</sub>) thiocarbonate (BOST), is easily synthesized and successfully applied to the 1,<i>n</i> (<i>n</i> ≥ 2)-trifluoromethylthioamination of alkenes under photocatalytic energy transfer conditions. This study not only achieves the radical trifluoromethylthioamination of olefins for the first time but also provides structurally important and diverse SCF<sub>3</sub>-featured amino acid esters and amino nitriles that were previously inaccessible.
Authors
- Sheng‐Qiang Lai
- Pengfei Zhao (ORCID: https://orcid.org/0000-0003-2034-7696)
- Luyi Zhu (ORCID: https://orcid.org/0000-0003-0774-8866)
- Zuo-Shuai Wang
- Xiaojian Wang (ORCID: https://orcid.org/0000-0002-1502-8781)
- Bing Han (ORCID: https://orcid.org/0000-0003-0507-9742)
Institutions
- State Key Laboratory of Chemical Engineering (CN)
- Lanzhou University (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2025-09-09
- DOI
- https://doi.org/10.1021/acs.orglett.5c03317
- Citations
- 1
- Primary Topic
- Fluorine in Organic Chemistry
- Type
- article
- Field-Weighted Citation Impact
- 0.79