Altered Corneal T-Cell Motility and Sensory Nerve Features in Older Adults With Human Immunodeficiency Virus Infection
Among older individuals with well-controlled HIV infection and clinically-normal ocular surface health, this study identifies subclinical group differences in corneal immune cells (potentially indicative of a heightened, pro-inflammatory activation state in the peripheral cornea) and corneal endothelial cell morphology that parallel those in chronic inflammatory disease. This study demonstrates the utility of Fun-IVCM to evaluate subclinical immune cell features in systemic disease, which could inform the future identification of biomarkers in immune-related conditions.
Authors
- Bao N. Nguyen (ORCID: https://orcid.org/0000-0002-3097-619X)
- S. M. Karunaratne (ORCID: https://orcid.org/0000-0003-1418-7278)
- Scott N. Mueller (ORCID: https://orcid.org/0000-0002-3838-3989)
- Laura Elizabeth Downie (ORCID: https://orcid.org/0000-0002-1596-2259)
- Phillip Bedggood (ORCID: https://orcid.org/0000-0001-5144-3694)
- Xinru Yu
- Andrew Metha (ORCID: https://orcid.org/0000-0003-2997-4362)
- Kevin J. Selva (ORCID: https://orcid.org/0000-0002-0780-9422)
- Stephen John Kent (ORCID: https://orcid.org/0000-0002-8539-4891)
- Mengliang Wu (ORCID: https://orcid.org/0000-0002-0142-6623)
- Holly R. Chinnery (ORCID: https://orcid.org/0000-0003-4238-4324)
- Amy W. Chung (ORCID: https://orcid.org/0000-0003-0020-9704)
- Julie Silvers
Institutions
- Lions Eye Institute (AU)
- The University of Melbourne (AU)
- Australian College of Optometry (AU)
- Melbourne Sexual Health Centre (AU)
- Peter Doherty Institute (AU)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2025-09-10
- DOI
- https://doi.org/10.1167/iovs.66.12.23
- Primary Topic
- Ocular Surface and Contact Lens
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- University of Melbourne