Abnormal choline transporter immunohistochemical staining in older children with chronic constipation not associated with Hirschsprung disease
In our cohort, ChT IHC showed an abnormal/aganglionic or equivocal pattern in 37% of patients with chronic constipation. As such, ChT IHC results should be interpreted with caution when performed on rectal biopsies in chronically constipated children.
Authors
- Lisa A. Teot
- Samuel Nurko (ORCID: https://orcid.org/0000-0003-0936-4807)
- Erin Alston (ORCID: https://orcid.org/0000-0002-1439-2258)
- Jeffrey D. Goldsmith (ORCID: https://orcid.org/0000-0003-4566-1307)
- Alejandro Flores (ORCID: https://orcid.org/0000-0002-5038-4706)
- Christopher Schottmiller
Institutions
- Boston Children's Hospital (US)
Publication Details
- Journal
- American Journal of Clinical Pathology
- Published
- 2025-08-14
- DOI
- https://doi.org/10.1093/ajcp/aqaf095
- Primary Topic
- Congenital gastrointestinal and neural anomalies
- Type
- article
- Field-Weighted Citation Impact
- 0.00