A Novel Neuropathological Subtype of Amyotrophic Lateral Sclerosis Characterised by Prominent Astroglial TDP‐43 Pathology
Summary This study identified a novel amyotrophic lateral sclerosis subtype with prominent astroglial phosphorylated TDP‐43 inclusions and minimal neuronal inclusions. The patients shared a clinical phenotype of flail arm variant of ALS. These observations suggest a more critical role for astroglia than previously recognised.
Authors
- Yuki Hatanaka (ORCID: https://orcid.org/0000-0003-3365-8506)
- Hiroya Naruse (ORCID: https://orcid.org/0000-0002-1190-0499)
- Tomoyasu Matsubara (ORCID: https://orcid.org/0000-0002-7559-8284)
- Shigeo Murayama (ORCID: https://orcid.org/0000-0001-9709-5242)
- Tatsushi Toda (ORCID: https://orcid.org/0000-0002-0717-1123)
- Yuishin Izumi (ORCID: https://orcid.org/0000-0002-3048-9041)
- Toshihiro Haga
- Ryosuke Miyamoto (ORCID: https://orcid.org/0000-0001-6434-9541)
- Mika Takahara
- Hiroyuki Morino (ORCID: https://orcid.org/0000-0002-5190-3547)
- Kiyoshi Matsukura
- Amuro Kondo
- Akira Arakawa (ORCID: https://orcid.org/0000-0002-9336-1168)
- Yuko Saito (ORCID: https://orcid.org/0000-0002-9974-8638)
Institutions
- Teikyo University Hospital (JP)
- NeuroDevelopment Center (US)
- Tokyo Metropolitan Institute of Gerontology (JP)
- The University of Tokyo (JP)
- Teikyo University (JP)
- Tokushima University (JP)
- The University of Osaka (JP)
Publication Details
- Journal
- Neuropathology and Applied Neurobiology
- Published
- 2025-09-10
- DOI
- https://doi.org/10.1111/nan.70036
- Citations
- 1
- Primary Topic
- Amyotrophic Lateral Sclerosis Research
- Type
- article
- Field-Weighted Citation Impact
- 1.39
Funders
- Japan Agency for Medical Research and Development
- Ministry of Health, Labour and Welfare
- Kato Memorial Bioscience Foundation
- Japan Society for the Promotion of Science