Patterns of extreme outlier gene expression suggest an edge of chaos effect in transcriptomic networks
We show that outlier patterns of gene expression are a biological reality occurring universally across tissues and species. Most of the outlier expression is spontaneous and not inherited. We suggest that the outlier patterns reflect edge of chaos effects that are expected for systems of non-linear interactions and feedback loops, such as gene regulatory networks.
Authors
- Sven Künzel (ORCID: https://orcid.org/0000-0003-4992-5963)
- Diethard Tautz (ORCID: https://orcid.org/0000-0002-0460-5344)
- Shelley S. Tworoger (ORCID: https://orcid.org/0000-0002-6986-7046)
- Cassandra A. Hathaway (ORCID: https://orcid.org/0000-0002-2919-0499)
- Wenyu Zhang (ORCID: https://orcid.org/0000-0002-2507-3033)
- Chen Xie (ORCID: https://orcid.org/0000-0002-6183-7301)
Institutions
- Oregon Health & Science University (US)
- Northwestern Polytechnical University (CN)
- Peking University (CN)
- Moffitt Cancer Center (US)
- Max Planck Institute for Evolutionary Biology (DE)
Publication Details
- Journal
- Genome biology
- Published
- 2025-09-09
- DOI
- https://doi.org/10.1186/s13059-025-03709-0
- Citations
- 3
- Primary Topic
- RNA Research and Splicing
- Type
- article
- Field-Weighted Citation Impact
- 1.61