<i>IGL</i> :: <i>CCND1</i> detected by optical genome mapping revises diagnosis of a B-cell lymphoma
We present a case of CD5+/CD10- small B-cell lymphoma that immunophenotypically resembled CLL but showed positive immunostaining for cyclin D1. The combination of the clinicopathologic findings and the CCND1 translocation involving IGL, detected by OGM, supported a revised diagnosis of MCL.
Authors
- Jeremiah Karrs (ORCID: https://orcid.org/0000-0002-5064-159X)
- Lauren M. Wainman (ORCID: https://orcid.org/0009-0001-2295-111X)
- Wasil Khan (ORCID: https://orcid.org/0000-0002-7785-2899)
- Prabhjot Kaur (ORCID: https://orcid.org/0000-0002-4735-7512)
- Jing Bao (ORCID: https://orcid.org/0000-0003-2273-4577)
- David D. Wilson (ORCID: https://orcid.org/0000-0002-6549-4174)
- Heather B. Steinmetz
- Michelle A Bickford
- Narcisa A Smuliac
- Kyle A Tonseth
- Soma Roy Chakraborty
- Farzana Murad
- Swaroopa PonnamReddy
- Liam L Donnely
Institutions
- Dartmouth College (US)
- Dartmouth–Hitchcock Medical Center (US)
Publication Details
- Journal
- American Journal of Clinical Pathology
- Published
- 2025-08-18
- DOI
- https://doi.org/10.1093/ajcp/aqaf096
- Citations
- 3
- Primary Topic
- Chronic Lymphocytic Leukemia Research
- Type
- article
- Field-Weighted Citation Impact
- 4.88