Interferon-induced miR-7705 modulates the anti-virus activity of cholesterol 25-hydroxylase
This study highlights the critical role of miR-7705 in regulating the antiviral effects of interferon (IFN) therapy, particularly in the context of chronic HBV infection. By identifying miR-7705 as a key modulator of CH25H, a protein essential for controlling HBV replication, our research provides new insights into the mechanisms that limit the effectiveness of IFN treatment. Targeting miR-7705 could improve the efficacy of IFN-based therapies, offering a potential strategy to better manage HBV and other viral infections. This research paves the way for developing adjunctive treatments that enhance the body's natural antiviral responses.
Authors
- Fengchao Xu
- Fan Yang (ORCID: https://orcid.org/0000-0002-9805-9099)
- Jing Xu (ORCID: https://orcid.org/0000-0003-1595-2138)
- Guangyun Tan (ORCID: https://orcid.org/0000-0003-4205-8481)
- Lei Yang (ORCID: https://orcid.org/0000-0002-0785-2084)
- Le Wang (ORCID: https://orcid.org/0000-0002-6142-7134)
- Xiaolu Li (ORCID: https://orcid.org/0000-0002-9845-1584)
- Fei Wang (ORCID: https://orcid.org/0009-0006-9673-7251)
- Yujia Zhu
- Pujun Gao (ORCID: https://orcid.org/0000-0002-0878-4271)
- Hongxiao Song
- Mian Huang (ORCID: https://orcid.org/0000-0001-5596-9693)
Institutions
- Jilin University (CN)
- First Hospital of Jilin University (CN)
- Jilin Medical University (CN)
- National Centre for Infectious Diseases (SG)
Publication Details
- Journal
- Journal of Virology
- Published
- 2025-09-10
- DOI
- https://doi.org/10.1128/jvi.01198-25
- Citations
- 1
- Primary Topic
- Hormonal Regulation and Hypertension
- Type
- article
- Field-Weighted Citation Impact
- 1.29