Low-Level Light Therapy Effect on Metabolites Measured by MR Spectroscopy in Patients with Moderate Traumatic Brain Injury: A Double-Blind, Randomized, Placebo-Controlled Clinical Trial
Despite the small sample size, MR spectroscopic imaging indicates a metabolic response in participants treated with LLLT compared with those receiving sham treatment. This potentially suggests a neuroprotective and anti-inflammatory effect from the acute administration of LLLT in individuals with moderate TBI.
Authors
- Michael R. Hamblin (ORCID: https://orcid.org/0000-0001-6431-4605)
- Suk‐Tak Chan (ORCID: https://orcid.org/0000-0001-6627-3173)
- Blair A. Parry (ORCID: https://orcid.org/0000-0002-6230-5286)
- Ramon Diaz‐Arrastia (ORCID: https://orcid.org/0000-0001-6051-3594)
- Arman Avesta (ORCID: https://orcid.org/0000-0002-6847-9818)
- Michael H. Lev (ORCID: https://orcid.org/0000-0003-0236-7319)
- Terry M. Rauch
- Michael Wenke (ORCID: https://orcid.org/0000-0002-2491-2296)
- Jarone Lee (ORCID: https://orcid.org/0000-0002-4532-8523)
- Jonathan Welt (ORCID: https://orcid.org/0009-0008-5642-5020)
- Benjamin J. Vakoc (ORCID: https://orcid.org/0000-0002-6623-3515)
- Eva‐Maria Ratai (ORCID: https://orcid.org/0000-0001-9476-6207)
- Nathaniel D. Mercaldo (ORCID: https://orcid.org/0000-0003-1658-6598)
- Maria Gabriela Figueiró Longo (ORCID: https://orcid.org/0000-0001-6819-4890)
- Rajiv Gupta (ORCID: https://orcid.org/0000-0002-5882-960X)
- Richard R. Anderson
- Lynn A. Drake
Institutions
- Office of the Secretary of Defense (US)
- MACOM (United States) (US)
- Harvard University (US)
- University of California, Irvine (US)
- University of Johannesburg (ZA)
- Massachusetts General Hospital (US)
- Athinoula A. Martinos Center for Biomedical Imaging (US)
- University of Pennsylvania (US)
Publication Details
- Journal
- American Journal of Neuroradiology
- Published
- 2025-09-09
- DOI
- https://doi.org/10.3174/ajnr.a8996
- Primary Topic
- Mitochondrial Function and Pathology
- Type
- article
- Field-Weighted Citation Impact
- 0.00