Predictive Value of Plasma Biomarkers in Tau‐ <scp>PET</scp> Transitions
In two cohorts, %p-tau217 was associated with tau-PET conversion, comparable to amyloid-PET. APS2 also predicted conversion in the MCSA cohort, whereas Aβ42/40 predicted conversion in the BioFINDER-2 cohort, which had more individuals with cognitive impairment. ANN NEUROL 2025;98:1249-1260.
Authors
- Val J. Lowe (ORCID: https://orcid.org/0000-0002-5612-1667)
- Clifford R. Jack (ORCID: https://orcid.org/0000-0001-7916-622X)
- Jonathan Graff‐Radford (ORCID: https://orcid.org/0000-0003-2770-0691)
- Jeremy A. Syrjanen (ORCID: https://orcid.org/0000-0001-5990-8206)
- Petrice M. Cogswell (ORCID: https://orcid.org/0000-0002-8128-4476)
- Alexa Pichet Binette (ORCID: https://orcid.org/0000-0001-5218-3337)
- Sebastian Palmqvist (ORCID: https://orcid.org/0000-0002-9267-1930)
- Erik Stomrud (ORCID: https://orcid.org/0000-0002-0841-5580)
- Alicia Algeciras‐Schimnich (ORCID: https://orcid.org/0000-0002-4455-6217)
- Ruben Smith (ORCID: https://orcid.org/0000-0001-7147-0112)
- Prashanthi Vemuri (ORCID: https://orcid.org/0000-0003-4286-0589)
- Ronald Carl Petersen (ORCID: https://orcid.org/0000-0002-8178-6601)
- Niklas Mattsson (ORCID: https://orcid.org/0000-0002-8885-7724)
- Oskar Hansson (ORCID: https://orcid.org/0000-0001-8467-7286)
- Walter K. Kremers (ORCID: https://orcid.org/0000-0001-5714-3473)
- David S. Knopman (ORCID: https://orcid.org/0000-0002-6544-066X)
- Christopher G. Schwarz (ORCID: https://orcid.org/0000-0002-1466-8357)
- Heather J. Wiste (ORCID: https://orcid.org/0009-0002-8833-2693)
Institutions
- Lund University (SE)
- Mayo Clinic in Arizona (US)
- Skåne University Hospital (SE)
- Mayo Clinic in Florida (US)
Publication Details
- Journal
- Annals of Neurology
- Published
- 2025-09-10
- DOI
- https://doi.org/10.1002/ana.78003
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00