Age‐related amyloid beta dynamics modeled with the generalized additive model for location, scale, and shape (GAMLSS) across diverse populations: Cross‐sectional trajectories and longitudinal validation
A generalized additive model for location, scale, and shape model was applied to examine age-related amyloid beta (Aβ) trajectories with baseline data. Trajectories were validated using longitudinal data, confirming model reliability. Non-Hispanic Whites exhibited steeper trajectories than Koreans, especially in apolipoprotein E ε4 carriers. Our approach enables scalable modeling of Aβ dynamics for Alzheimer's disease prevention strategies. Findings highlight the importance of multi-ethnic research in Aβ accumulation.
Authors
- Min Young Chun (ORCID: https://orcid.org/0000-0003-3731-6132)
- Duk Lyul Na (ORCID: https://orcid.org/0000-0002-0098-7592)
- Sunmin Yim (ORCID: https://orcid.org/0000-0001-9552-4189)
- Jun Pyo Kim
- Kyunga Kim (ORCID: https://orcid.org/0000-0002-0865-2236)
- Hyemin Jang (ORCID: https://orcid.org/0000-0003-3152-1274)
- Suzanne E. Schindler (ORCID: https://orcid.org/0000-0002-1680-1465)
- Sungjoo Lee (ORCID: https://orcid.org/0000-0003-1284-3593)
- Sang Won Seo (ORCID: https://orcid.org/0000-0002-8747-0122)
- Han Jo Kim (ORCID: https://orcid.org/0000-0001-7880-690X)
- Eun Hye Lee (ORCID: https://orcid.org/0000-0003-2570-3442)
- Daeun Shin (ORCID: https://orcid.org/0000-0003-4834-1026)
- Michael Walter Weiner (ORCID: https://orcid.org/0000-0002-0144-1954)
- Heoung‐Keun Kang (ORCID: https://orcid.org/0009-0009-5896-4615)
Institutions
- Ulsan College (KR)
- University of California, San Francisco (US)
- Yonsei University (KR)
- Washington University in St. Louis (US)
- Asan Medical Center (KR)
- Samsung Medical Center (KR)
- Seoul National University Hospital (KR)
- University of California System (US)
- University of Ulsan (KR)
- Yonsei University Health System (KR)
- Indiana University School of Medicine
- Indiana University – Purdue University Indianapolis (US)
- Sungkyunkwan University (KR)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-09-01
- DOI
- https://doi.org/10.1002/alz.70675
- Citations
- 1
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 1.47
Funders
- National Research Foundation
- Korea Health Industry Development Institute
- National Research Foundation of Korea
- Ministry of Science and ICT, South Korea
- Samsung
- Korea National Institute of Health