Prognostic models for radiation-induced complications after radiotherapy in head and neck cancer patients

Amongst 592 developed models, a limited number had adequate quality. Only one-fifth were externally validated, of which, only nine models at least twice. These nine models showed acceptable discriminative performance at external validation. However, their calibration performance was not always reported. Furthermore, most validation studies were judged as having high ROB, mainly due to problems in the analysis domain. In conclusion, this review shows the need for more external validation studies before the implementation of developed models in clinical practice and improvement of the quality of conducting and reporting of prediction model studies.

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Publication Details

Journal
Cochrane Database of Systematic Reviews
Published
2025-09-10
DOI
https://doi.org/10.1002/14651858.cd014745.pub2
Primary Topic
Head and Neck Cancer Studies
Type
article
Field-Weighted Citation Impact
0.00
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article

Prognostic models for radiation-induced complications after radiotherapy in head and neck cancer patients

Johannes A. Langendijk, E. Clementel, Marjan Sharabiani, Lotta Meijerink et al.
Cochrane Database of Systematic Reviews
Head and Neck Cancer Studies
article

Prognostic models for radiation-induced complications after radiotherapy in head and neck cancer patients

Johannes A. Langendijk, E. Clementel, Marjan Sharabiani, Lotta Meijerink, Jungyeon Choi, Artuur Leeuwenberg, Ewoud Schuit, Makbule Tambaş, Johanna AAG Damen, Demy L. Idema, Toshihiko Takada, Zoë S Dunias, Jan F. Nauta, Karel Moons
article en

Abstract

Amongst 592 developed models, a limited number had adequate quality. Only one-fifth were externally validated, of which, only nine models at least twice. These nine models showed acceptable discriminative performance at external validation. However, their calibration performance was not always reported. Furthermore, most validation studies were judged as having high ROB, mainly due to problems in the analysis domain. In conclusion, this review shows the need for more external validation studies before the implementation of developed models in clinical practice and improvement of the quality of conducting and reporting of prediction model studies.

Cochrane Database of Systematic ReviewsVol. 2025(9)
Fukushima Medical University (JP), University Medical Center Groningen (NL), University of Groningen (NL), Utrecht University (NL), University Medical Center Utrecht (NL), Aerospace Research Institute (IR), European Organisation for Research and Treatment of Cancer (BE)
Openalex Percentile: Top 68%
Head and Neck Cancer Studies
DOIOpen Access PDFOpenAlex
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Prognostic models for radiation-induced complications after radiotherapy in head and neck cancer patients — Johannes A. Langendijk, E. Clementel, et al. · Cochrane Database of Systematic Reviews (2025) | TGRS Research Map | TGRS